Summary of work to be performed:

• Develop and execute computational strategies in pursuit of protein modeling, structure-based, ligand-based, focused compound and chemical library designs broadly applied to lead generation & optimization.

Specific duties:

Work with TransTech scientists in;

• Lead discovery activities, identifying active compounds and building target - binding hypotheses using TransTech’s Tapered^® platform.  Develop enabling technologies that build on the existing proprietary TTPredict^® technology platform.

• Lead optimization activities for one or more TransTech drug discovery programs, employing computationally – based methods to improve potency, efficacy, and/or ADME properties of lead compounds, in agreement with goals and objectives of the program team.

Aptitude and personality characteristics critical to job function:

• High energy, active personality and commitment to science and drug discovery


• Excellent organization and presentation skills


• Takes a proactive role in stimulating communications with scientific colleagues in biology, chemistry, and development departments


• Commitment to teamwork and achievement

Education/Experience requirements:

• 
  
  Ph.D. degree in physical or biological sciences or related disciplines with 5+ years experience in computational chemistry/modeling in a pharmaceutical setting.

Experience and skills:

• Strong expertise in protein modeling, docking and scoring,  and binding energy prediction


• Experience with pharmacophore & QSAR/QSPR model development, de novo approaches, bioinformatics/chemoinformatic data mining and modeling methods.


• Knowledge & experience in the application of relevant computational chemistry software from Chemical Computing Group, Accelrys, Tripos, Schroedinger, OpenEye, Daylight/MDL, AMBER/CHARMM, AutoDock, GOLD, etc.


•  Knowledge & experience in statistical techniques that include SVM, Neural Nets, Genetic & Evolutionary algorithms, Random Forest, etc.


• Familiarity in Unix/Linux operating systems with proficiency in modern scripting languages like Perl/Python and programming languages that include Java, Fortran, C/C++.


• Knowledge of organic and medicinal chemistry

TransTech Pharma is an Equal Opportunity Employer.