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Director, Immunosuppression


Job Summary

Beverly Hills, CA
Other/Not Classified
Job Type
Full Time
Career Level
Experienced (Non-Manager)
Job Reference Code

Director, Immunosuppression

About the Job


Pfizer Cancer Immunology Discovery (CID) is the South San Francisco unit within the Oncology division of Pfizer Worldwide Research & Development. CID is dedicated to developing new protein therapeutics to improve human life by redirecting the immune system against cancer. CID researchers apply the latest scientific knowledge and novel approaches to discover truly innovative Immuno-Oncology therapeutics. Cooperation and support for a high level of scientific freedom is encouraged in this small biotech-like environment to find the best answers to biological questions, with the benefit of large pharma resources.

We are seeking to hire the head of our tumor microenvironment program. The candidate should be a highly motivated and accomplished scientist with demonstrated expertise in understanding and modulating the tumor microenvironment. This position is responsible for defining the strategy for Pfizer’s large molecule IO intervention targeting the immunosuppressive tumor microenvironment, which includes establishing and implementing new programs to target inhibitory cell types such as tumor infiltrating myeloid cells and suppressive stromal cells. The successful development of new innovative therapeutics will require close collaboration with a variety of inter-disciplinary colleagues including clinicians, protein engineers, and target identification and biomarker researchers.


Contribute to overall strategy for cancer immunology at CID and defining a strategy for large molecule IO intervention targeting the immunosuppressive tumor microenvironment

  • Supervise and mentor several teams committed to delivering IND-enabling packages over the next 2-4 years
  • Collaborate with immuno-oncology, protein engineering, computational biology, and clinical development groups to pursue the most promising drug candidates through clinical trials.
  • Supervise a group conducting target validation for new targets
  • Participate in collaboration on novel IO targets with internal and external collaborators.
  • Lead the latest scientific advancements in the field as a thought leader and spokesperson for Pfizer IO research, especially in the field of the tumor microenvironment
  • Contribute to a culture that embraces continuous learning, development, and collaboration


  • PhD with 10-15 years post-doctoral training with significant relevant experience in cancer immunotherapy including myeloid biology and/or tumor stroma biology
  • Experience managing a large team is essential
  • Knowledge of cellular and molecular immunology
  • Ability to design and supervise all aspects of in vitro and in vivo cancer immunotherapy models
  • Track record of publications and innovation
  • Ability to design and deliver novel solutions to challenging problems
  • Pro-active attitude and strong desire to discover novel biology and potential new drugs
  • Strong oral presentation and communication skills

Other Requirements:

  • Ability to perform complex data analysis
  • Ability to analyze and interpret work published in the field and use it to place our work in context


  • Industry experience, including regulatory agency interaction is highly desired, including experience of target validation and candidate selection

Travel Requirements

  • Role requires travel

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.  Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA.   Pfizer is an E-Verify employer.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure.  Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act.  Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government.  If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

Other Job Details:

  • Additional Location Information: South San Francisco, CA
  • Eligible for Relocation Package
  • Eligible for Employee Referral Bonus

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.


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