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Post-Doc Fellow

Postdoctoral position available:

The Escayg lab uses a combination of human and mouse genetics to identify novel genes and pathways that give rise to inherited neurological disorders. Of particular interest is the role voltage-gated ion channels play in episodic diseases, such as epilepsy. The human genetics component of our research involves analyzing families with inherited epilepsy to identify causal mutations. Once identified, mice carrying these causal mutations are generated and studied to shed light on the mechanisms of epilepsy. Mouse models are evaluated on a wide variety of parameters, including alterations in seizure threshold, behavior, EEG/sleep profile, brain histology and electrophysiology, as well as their response to anticonvulsant medications.

We are currently seeking a highly motivated postdoctoral fellow to work on an NIH funded project. The goal of this study is evaluate a novel strategy for the treatment of epilepsy. The approach will involve the generation of an adeno-associated virus (AAV) short hairpin RNA (shRNA) expression vector against a target gene. This reagent will be injected into the mouse hippocampus and evaluated for its ability to raise seizure thresholds in wild-type mice and reduce disease severity in mouse models of epilepsy. In addition to this specific project, the successful applicant will also have the opportunity to participate in additional ongoing research projects.

Interested applicants should provide a CV and contact information for three individuals who are familiar with your research including names, titles, and contact information as separate attachments; send to Andrew Escayg via e-mail at: aescayg@genetics.emory.edu

Preferred Qualifications
Experience with stereotaxic surgery/injections is essential. Prior experience with AAV-shRNA vectors will be an asset. The applicant should also be competent in basic molecular biology techniques such as Southern, Northern and Western blot analysis, PCR, and immunocytochemistry.
Additional Job Details NOTE: PLEASE DO NOT APPLY ONLINE FOR THIS POSITION. APPLY DIRECTLY TO THE DEPARTMENT USING THE INFORMATION PROVIDED ABOVE.
This position involves: Not Applicable

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