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Postdoctoral Fellow, Cancer Im...

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Job Summary

Company
Pfizer
Location
Beverly Hills, CA
Industries
Other/Not Classified
Job Type
Full Time
Employee
Career Level
Experienced (Non-Manager)
Job Reference Code
4903_4704421

Postdoctoral Fellow, Cancer Immunology

About the Job

ROLE SUMMARY

We are seeking a driven and accomplished postdoctoral fellow to join the Cancer Immunology Discovery (CID) group within the Oncology R&D (WRD) unit of Pfizer in South San Francisco, California.

The successful candidate with lead a research project to understand how epigenetic mechanisms control the anti-tumor immune response, and to translate the findings into better therapies with curative potential for cancer patients.

The project builds on promising preliminary data and applies cutting-edge technologies to address what is to date a major scientific question with great clinical implications. Guided by experienced mentors with strong academic track records, the successful candidate will study fundamental questions in cancer immunology with the goal of publishing in high-impact journals. The postdoc will also interact extensively with leading scientists in small and large molecule drug discovery, collaborate with computational, early clinical, and translational oncology colleagues across Pfizer, present in internal and external conferences, and receive mentorship to become a prolific independent scientific investigator.

ROLE RESPONSIBILITIES                                

The successful candidate will work independently, but with guidance by experienced mentors, to:

  • Discover the novel mechanisms through which epigenetic enzymes regulate T cell activation, differentiation, trafficking and exhaustion, in combination with I-O agents.
  • Design and perform studies to evaluate the anatomical distribution, persistence and function of antigen-specific T cells in preclinical models of cancer.
  • Collaborate with teams in tumor biology, protein engineering, computational biology, clinical development to discover novel biology and as a result identify better treatments for cancer patients.
  • Present at group meetings, internal and external conferences, and publish in high impact journals.
  • Contribute to building a culture that embraces scientific excellence, integrity, effectiveness, humility, continuous learning and team work.

BASIC QUALIFICATIONS

  • Ph.D. in Immuno-oncology, Immunology, Cancer Biology or a comparable biological science, with a strong track record of scientific publications.
  • 0-4 years of postdoctoral experience.
  • Solid hands-on experience with conventional immunological techniques: immune cell isolation, multi-color flow cytometry, in vitro immune cell functional assays and in vivo tumor models.
  • Experience in assessing T cell function, differentiation, exhaustion and memory development.
  • Must have excellent organization and planning skills, the ability to work in a fast-paced environment independently and as part of a team. Excellent verbal and written communication, and strong motivation with a dedicated work ethic.
  • Able to master new concepts and techniques quickly.

PREFERRED QUALIFICATIONS

  • 2+ years research experience in T cell biology and/or epigenetics.
  • Strong understanding of innate and adoptive immune systems.
  • Prior experience or a strong interest in developing novel immunotherapies for cancer.
  • Hands-on experience in qRT-PCR, ELISA, Western blotting, ChIP-seq, RNA-seq, ATAC-seq and CyTOF is desirable.
  • Hands-on experience in CRISPR, RNAi, lentiviral transduction and exogenous gene expression is a plus.
  • Hands-on experience in syngeneic and spontaneous tumor models, adoptive cell transfer is desirable.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.  Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA.   Pfizer is an E-Verify employer.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure.  Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act.  Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government.  If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

Other Job Details:

  • Last Date to Apply for Job: July 12, 2018

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.

 

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