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Principal Scientist, Toxicolog...


Job Summary

Groton, CT
Other/Not Classified
Job Type
Full Time
Career Level
Experienced (Non-Manager)
Job Reference Code

Principal Scientist, Toxicology

About the Job

Are you driven to discover the cure?

Science is the foundation of Pfizer.  This is why it’s no surprise that our scientists are among the
best in the world. We arm them with the resources and technology they need to solve some of the world’s most complex  health challenges for unmet medical needs.

As a member of the Genetic Toxicology Center of Excellence (CoE) within Drug Safety Research and Development (DSRD), this genetic/cellular toxicology expert will evaluate the potential of therapeutics to cause DNA damage.  Our CoE in Groton, CT partners closely with our research units: Oncology, Rare Disease, I&I and our Internal Medicine Research Unit.

Your work will include the development of high throughput/high content methods utilizing image analysis for the purpose of identifying mechanisms of genotoxicity/cellular toxicity.

You  will interface with drug discovery teams in the US and across the globe  to provide genetic toxicology expertise.  Specifically,  communicate the interpretation and implication of results from standard assays and investigational studies.

Within the CoE, you will guide the design of experiments, mentor and develop other scientists and maintain an awareness of current scientific literature.

Additionally, you will influence the external environment via presentations, publications and membership in consortia.

You should have strong interpersonal and communication skills required to build networks and partnerships.

Experience with high content cellular imaging and a strong background in cellular biology would be desirable.  Genetic toxicology training will be provided.

Further develop as a genetic toxicology subject matter expert
Provide genetic toxicology expertise to DSRD and discovery project teams by interpreting and communicating the results of standard and investigational genotoxicity studies.

Integrate data and present findings and interpretations in written and oral reports to peers, management, and regulatory agencies

Explore, develop and apply novel in vitro assay systems using high content image analysis to study mechanism of genotoxicity

Guide the design of experiments and mentor other scientists
Influence the external environment via presentations, publications and membership in consortia.

PhD in cellular biology, molecular biology, molecular toxicology, cancer biology or a related field
4+ years experience working in the field with associated publication and presentation record

Experience with high content data analysis and computational biology
Columbus Software
Therapeutic area research experience- such as Oncology, I&I, Rare Disease, Immunometabolism

**Some travel to attend scientific meetings and consortia (2-3 times per year)

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.  Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA.   Pfizer is an E-Verify employer.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure.  Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act.  Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government.  If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

Eligible for Relocation Package
Eligible for Employee Referral Bonus

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.


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